Home Health and wellness Landmark Publication on Vitamin C for COVID-19

Landmark Publication on Vitamin C for COVID-19

by kyngsam

No matter what the mainstream media need you to assume, many are beginning to understand the reality, which is that each vitamin C (ascorbic acid) and vitamin D have an unlimited quantity of analysis exhibiting they supply vital immune perform enhancements, and that your immune perform is your frontline protection towards all sickness, together with COVID-19.

As reported within the paper “Optimum Dietary Standing for a Properly-Functioning Immune System Is an Necessary Issue to Shield Towards Viral Infections,” printed April 23, 2020:1

“The position diet performs in supporting the immune system is well-established. A wealth of mechanistic and medical information present that nutritional vitamins, together with nutritional vitamins A, B6, B12, C, D, E, and folate; hint components, together with zinc, iron, selenium, magnesium, and copper; and the omega-Three fatty acids eicosapentaenoic acid and docosahexaenoic acid play vital and complementary roles in supporting the immune system.

Insufficient consumption and standing of those vitamins are widespread, resulting in a lower in resistance to infections and as a consequence a rise in illness burden.”

Excessive-Dose Vitamin C Acts as an Antiviral Drug

As defined within the video above by Dr. Andrew Saul, editor-in-chief of the Orthomolecular Drugs Information Service, at extraordinarily excessive doses, vitamin C really acts as an antiviral drug, successfully inactivating viruses.

His Tokyo presentation, “Orthomolecular Drugs and Coronavirus Illness: Historic Foundation for Dietary Remedy,” highlights the truth that when used as a therapy, excessive doses of vitamin C — typically 1,000 instances greater than the U.S. Really helpful Dietary Allowance (RDA) — are wanted.

It is a cornerstone of medical science that dose impacts therapy end result, however this premise is not accepted relating to vitamin remedy the way in which it’s with drug remedy. Most vitamin C analysis has used insufficient, low doses, which do not result in medical outcomes.

“The medical literature has ignored over 80 years of laboratory and medical research on high-dose ascorbate remedy,” Saul notes, including that whereas it is broadly accepted that vitamin C is helpful in preventing sickness, controversy exists over to what extent. “Average portions present efficient prevention,” he says, whereas “massive portions are therapeutic.”

Landmark Paper Places Vitamin C on the COVID-19 Remedy Map

Whereas well being authorities and mainstream media have ignored, if not outright opposed, the usage of vitamin C and different dietary supplements within the therapy of COVID-19, citing lack of medical proof, we now have a landmark evaluation2 recommending the usage of vitamin C as an adjunctive remedy for respiratory infections, sepsis and COVID-19.

The evaluation,3 printed December 7, 2020, within the journal Vitamins, was co-written by Dr. Paul Marik who, in 2017, developed a groundbreaking vitamin C-based treatment for sepsis. Marik is now heading up the Entrance Line COVID-19 Crucial Care Alliance,4 which has developed a extremely profitable therapy for COVID-19.

The COVID-19 protocol was initially dubbed MATH+ (an acronym based mostly on the important thing parts of the therapy), however after a number of tweaks and updates, the prophylaxis and early outpatient therapy protocol is now generally known as I-MASK+5 whereas the hospital therapy has been renamed I-MATH+,6 because of the addition of the drug Ivermectin. Vitamin C stays a central element of this therapy, although.

(The 2 protocols7,8 can be found for obtain on the FLCCC Alliance web site in a number of languages. The medical and scientific rationale for the I-MATH+ hospital protocol has additionally been peer-reviewed and was printed within the Journal of Intensive Care Drugs9 in mid-December 2020.) As defined within the Vitamins evaluation summary:10

“There are restricted confirmed therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating results make it a possible therapeutic candidate, each for the prevention and amelioration of COVID-19 an infection, and as an adjunctive remedy within the important care of COVID-19.

This literature evaluation focuses on vitamin C deficiency in respiratory infections, together with COVID-19, and the mechanisms of motion in infectious illness, together with help of the stress response, its position in stopping and treating colds and pneumonia, and its position in treating sepsis and COVID-19.

The proof to this point signifies that oral vitamin C (2-Eight g/day) might scale back the incidence and period of respiratory infections and intravenous vitamin C (6-24 g/day) has been proven to scale back mortality, intensive care unit (ICU) and hospital stays, and time on mechanical air flow for extreme respiratory infections …

Given the favorable security profile and low value of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it could be worthwhile testing sufferers’ vitamin C standing and treating them accordingly with intravenous administration inside ICUs and oral administration in hospitalized individuals with COVID-19.”

Worldwide Vitamin C Marketing campaign Launched

In a December 16, 2020, motion alert,11 Rob Verkerk, Ph.D., founder and scientific director of the Alliance for Pure Well being, introduced the launch of a world vitamin C marketing campaign12 in response to the landmark evaluation, which “places all of the arguments and science in a single, neat place.”

As famous by Verkerk, there are a number of causes to take supplemental vitamin C. First, your physique can not make it. Second, most individuals don’t get ample quantities from their weight loss plan and, third, your physique’s requirement for vitamin C can enhance 10-fold at any time when your immune system is challenged by an an infection, illness or bodily trauma.

In truth, the Vitamins evaluation13 factors out that it is common for hospitalized sufferers to have overt vitamin C deficiency, outlined as a blood stage at or beneath 11 µmol/L. That is significantly true for older sufferers and people hospitalized for respiratory infections.

In accordance with the authors, “Vitamin C concentrations are three to 10 instances larger within the adrenal glands than in some other organ. It’s launched from the adrenal cortex below circumstances of physiological stress (ACTH stimulation), together with viral publicity, elevating plasma ranges fivefold.” In his motion alert, Verkerk notes:14

“Taking vitamin C as a preventative after which, upping your consumption when you’re contaminated, is a no brainer. So is utilizing vitamin C intravenously for these with acute respiratory infections, or sepsis, in important care.

A lot so, that we argue — given the now obtainable proof — that docs and different well being professionals who keep away from suggestions on vitamin C in relation to COVID illness prevention and therapy, ought to be thought of medically negligent …

There’s ample proof to point out that dietary supplements like zinc, vitamin C, and vitamin D may help stop and deal with COVID-19, however we’re prevented from studying about these advantages by the federal authorities.

As a result of dietary supplements should not, and might by no means turn out to be, FDA-approved, they can not declare to have an effect on illness, even once we know they’ll. This nonsense has to cease.”

How Vitamin C Works

As talked about, the Vitamins evaluation15 particulars vitamin C’s mechanisms of motion and the way it helps in instances of infectious illness, together with the frequent chilly, pneumonia, sepsis and COVID-19. For starters, vitamin C has the next primary properties:

  • Anti-inflammatory
  • Immunomodulatory
  • Antioxidant
  • Antithrombotic
  • Antiviral

Useful antiviral results apply to each the innate and adaptive immune methods. When you have got an an infection, vitamin C improves your immune perform partially by selling the event and maturation of T-lymphocytes, a sort of white blood cell that’s a vital a part of your immune system.

Phagocytes, immune cells that kill pathogenic microbes, are additionally ready to absorb oxidized vitamin C and regenerate it to ascorbic acid. With regard to COVID-19 particularly, vitamin C:16

Helps downregulate inflammatory cytokines, thereby decreasing the chance of a cytokine storm. It additionally reduces irritation by means of the activation of NF-κB and by rising superoxide dismutase, catalase and glutathione. Epigenetically, vitamin C regulates genes concerned within the upregulation of antioxidant proteins and downregulation of proinflammatory cytokines

Protects your endothelium from oxidant harm

Helps restore broken tissues

Upregulates expression of Kind-1 interferons, your major antiviral protection mechanism, which SARS-CoV-2 downregulates

Eliminates ACE2 upregulation induced by IL-7. That is significantly noteworthy, because the ACE2 receptor is the entry level for SARS-CoV-2 (the virus’ spike protein binds to ACE2)

Seems to be a strong inhibitor of Mpro, a key protease (enzyme) in SARS-CoV-2 that prompts viral nonstructural proteins

Regulates neutrophil extracellular lure formation (NETosis), a maladaptive response that leads to tissue harm and organ failure

Enhances lung epithelial barrier perform in an animal mannequin of sepsis by selling epigenetic and transcriptional expression of protein-channels on the alveolar capillary membrane that regulate alveolar fluid clearance

Mediates the adrenocortical stress response, significantly in sepsis

The graph beneath, from the Vitamins evaluation, illustrates the important thing methods wherein vitamin C ameliorates the pathology seen in COVID-19.

Nebulized Peroxide Could Be Even Higher

The gorgeous graphic above makes it actually clear that one of many major ways in which vitamin C works is thru the technology of reactive oxygen species. Guess what the first one is? In the event you guessed hydrogen peroxide give your self a excessive 5!

It’s extremely probably that the peroxide varieties a really highly effective signaling perform that stimulates the immune system to defeat no matter viral risk it’s uncovered to. This is without doubt one of the explanation why nebulized peroxide is my absolute favourite intervention for acute viral sicknesses. It’s extremely efficient, cheap and has no unwanted effects when used on the very low doses beneficial (0.1%, which is 30 instances much less concentrated than common drugstore 3% peroxide).

My video beneath discusses the main points of how you should use this remedy. The secret is to have your nebulizer already bought and able to go in order that it’s locked and loaded and you do not have to exit and buy something when you or a cherished one will get sick. You possibly can nonetheless use vitamin C with the peroxide, as they probably have a strong synergy and use completely different complimentary mechanisms.

Since you aren’t utilizing full power 3% peroxide and diluting it by 30 to 50 instances, it’s unlikely the stabilizers will current an issue, however to be secure, it’s best to make use of FOOD-GRADE peroxide. Additionally, don’t dilute it with plain water as the shortage of electrolytes within the water can harm your lungs when you nebulize it. As a substitute, use saline or add a small quantity of salt to the water to eradicate this danger.

peroxide dilution charts

Medical Proof

The Vitamins evaluation17 additionally consists of medical proof for the position of vitamin C in COVID-19, noting that early oral supplementation may assist stop a light case from creating into one thing extra critical. In sufferers with important signs, intravenous administration of vitamin C has been proven to hurry up restoration, decreasing each ICU stays and mortality.

Apparently, vitamin C deficiency and COVID-19 share lots of the similar danger components, together with male gender, darker pores and skin, older age and comorbidities resembling diabetes, hypertension and COPD. All of those subgroups are at elevated danger for extreme COVID-19 and, in line with the authors, all “have additionally been proven to have decrease serum vitamin C ranges.”

Commenting on the medical proof supporting the usage of vitamin C within the therapy of COVID-19, the authors write:18

“There are at present 45 trials registered on Clinicaltrials.gov investigating vitamin C with or with out different therapies for COVID-19. Within the first RCT to check the worth of vitamin C in critically sick COVID-19 sufferers, 54 ventilated sufferers in Wuhan, China, have been handled with a placebo (sterile water) or intravenous vitamin C at a dose of 24 g/day for 7 days …

The extra severely sick sufferers with SOFA [sequential organ failure assessment] scores ≥ Three within the vitamin C group exhibited a discount in 28-day mortality: 18% versus 50% in univariate survival evaluation (Determine 2). No study-related adversarial occasions have been reported.”

Determine 2 beneath, from model 1 of the research,19 “Excessive-Dose Vitamin C Infusion for the Remedy of Critically Unwell COVID-19,” posted on the preprint server Analysis Sq. August 10, 2020 (up to date September 23, at which level it was renamed20), exhibits the 28-day mortality charges between critically sick COVID-19 sufferers given high-dose IV vitamin C (HDIVC) in comparison with these given a placebo.

28 day mortality rates

The Nutrient evaluation additionally summarizes findings from different COVID-19 trials utilizing vitamin C, in addition to a number of case reviews:21

“Within the UK, the Chelsea and Westminster hospital ICU, the place grownup ICU sufferers have been administered 1 g of intravenous vitamin C each 12 h along with anticoagulants, has reported 29% mortality, in comparison with the common 41% reported by the Intensive Care Nationwide Audit and Analysis Centre (ICNARC) for all UK ICUs …

The Frontline COVID-19 Crucial Care Skilled Group (FLCCC), a bunch of emergency drugs consultants, have reported that, with the mixed use of 6 g/day intravenous vitamin C (1.5 g each 6 h), plus steroids and anticoagulants, mortality was 5% in two ICUs within the US (United Memorial Hospital in Houston, Texas, and Norfolk Basic Hospital in Norfolk, Virginia), the bottom mortality charges of their respective counties.

A case report of 17 COVID-19 sufferers who got 1 g of intravenous vitamin C each Eight h for Three days reported a mortality price of 12% with 18% charges of intubation and mechanical air flow and a major lower in inflammatory markers, together with ferritin and D-dimer, and a development in direction of lowering FiO2 necessities.

One other case of sudden restoration following high-dose intravenous vitamin C has additionally been reported. Whereas these case reviews are topic to confounding and should not prima facie proof of results, they do illustrate the feasibility of utilizing vitamin C for COVID-19 with no adversarial results reported.”

How A lot Vitamin C Do You Want?

As detailed within the introduction of the Vitamins evaluation,22 primates and people are depending on an enough provide of vitamin C from vegetables and fruit. Gorillas want 4.5 grams a day, whereas smaller primates weighing round 7.5 kilos want about 600 mg per day. This provides us a clue as to what the human requirement is perhaps, and it is fairly a bit larger than the each day beneficial consumption. In accordance with the authors:23

“The EU Common Requirement of 90 mg/day for males and 80 mg/day for ladies is to keep up a traditional plasma stage of 50 µmol/L, which is the imply plasma stage in UK adults. That is ample to stop scurvy however could also be insufficient when an individual is below viral publicity and physiological stress.

An professional panel in cooperation with the Swiss Society of Nutrition beneficial that everybody complement with 200 mg ‘to fill the nutrient hole for the overall inhabitants and particularly for the adults age 65 and older. This complement is focused to strengthen the immune system.’ The Linus Pauling Institute recommends 400 mg for older adults (>50 years outdated).

Pharmacokinetic research in wholesome volunteers help a 200-mg each day dose to provide a plasma stage of circa 70 to 90 µmol/L. Full plasma saturation happens between 1 g each day and three g each 4 hours, being the best tolerated oral dose, giving a predicted peak plasma focus of circa 220 µmol/L.

The identical dose given intravenously raises plasma vitamin C ranges roughly tenfold. Increased intakes of vitamin C are more likely to be wanted throughout viral infections with 2–Three g/day required to keep up regular plasma ranges between 60 and 80 µmol/L. Whether or not larger plasma ranges have extra profit is but to be decided, however could be per the outcomes of the medical trials mentioned on this evaluation.”

Whereas high-dose vitamin C regimens usually name for intravenous administration, if treating a viral an infection at house (be it COVID-19 or one thing else), you could possibly use oral liposomal vitamin C, as this lets you take far larger doses with out inflicting free stools.

You possibly can take as much as 100 grams of liposomal vitamin C with out issues and get actually excessive blood ranges, equal to or larger than intravenous vitamin C. I view that as an acute therapy, nevertheless. I discourage individuals from taking mega doses of vitamin C regularly if they are not really sick, as a result of it’s basically a drug — or not less than it really works like one.

Saul, who has labored with and beneficial vitamin C for many of his skilled life suggests taking “sufficient vitamin C to be symptom-free,” no matter dosage that is perhaps. Once you’re effectively, you usually do not want greater than the 200 mg to 400 mg beneficial within the quote above.

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